Effectiveness of a native Type I Collagen matrix plus polyhexamethylene biguanide (PHMB) antimicrobial in the treatment of pressure injuries in a real-world setting

Objective: To analyze the subgroup of Pressure Injuries (PRIs) in the 28 site, prospective, non-interventional, PCMP registry (RESPOND)(a) that evaluated the real-world effectiveness of PCMP(b) (native Type I Collagen matrix plus PHMB; polyhexamethylene biguanide antimicrobial) on chronic and acute wounds. Methods: PCMP is intended for the management of partial and full thickness wounds (except 3rd degree burns) and as an effective barrier to reduce microbes penetrating through the dressing. All patients (n=307) in RESPOND received PCMP. Male and female patients, ≥18 years with cutaneous wounds not including third degree burns were eligible for participation. Wounds ≥0.2 and 200 cm were included. PCMP was used for up to 32 weekly visits. The analyses included 45 (15%) Pressure Injuries (PRIs). PCMP-treated wounds also included: 67 (22%) VLUs; 62 (20%) Diabetic Foot Ulcers (DFUs), 54 (18%) Post-Surgical Wounds (PSWs), and 79 (26%) Other wounds. All wounds (n=307) and subgroups were analyzed to determine the frequency and median time to wound closure using Kaplan-Meier (K-M) methods. Results: For the cohort of PCPM-treated PRIs (n=45), mean baseline area, duration, depth, and volume were 12.9 cm2,  months, 0.8 cm, and 15.2 cm3, respectively. Frequencies of wound closure were 18, 27, 39, 49 and 62% at week 8, 12, 16, 24, and 32, respectively. The median time to wound closure was 32 weeks. Analyses of wound closure for All, DFUs, VLUs, PSWs, and Other wounds showed frequencies of 73, 51, 72, 96, and 67%, respectively. Median times to wound closure were 17, 31, 22, 12, and 14 weeks. Conclusions: PRIs in the PCMP registry showed a frequency and median time to wound closure of 62% and 32 weeks, respectively. All wounds showed 73% and 17 weeks. PCMP appears to be a useful adjunct in the treatment of PRIs and other wound types.