Caregiver Insights on Naloxone to Reverse Opioid/Fentanyl Overdosing

Abstract: Introduction: The aim of this research was to gain caregiver insights on their previous use and current attitudes of naloxone to reverse opioid overdoses, including different routes for administration. This research also looked to identify knowledge gaps related to the understanding of the risk and prevalence of fentanyl. Methods: Qualitative interviews were conducted with 19 caregivers of a friend/family member at risk, or with a history of an opioid overdose. These caregivers had a mixed history of prior naloxone use with almost exclusively intranasal products. Participants were tested on the knowledge of overdose risks and fentanyl, subsequently presented with background information on fentanyl, , and then provided information for intranasal and intramuscular naloxone products. A moderator then asked for their opinions and understanding on the information and products they had just received. Results: Caregivers already familiar with health risks of fentanyl were more likely to carry naloxone compared to those without understanding of the risks. However, once provided information on fentanyl those caregivers responded differently: they expressed more concern and understood the need to be prepared and equipped with a sufficient amount of naloxone. The higher dose intramuscular naloxone product was preferred by 18 of 19 caregivers despite the significant familiarity with the intranasal product. Reasons given for product preference were 1) fast absorption/action 2) greater probability to reverse fentanyl overdoses with one dose. Conclusions: There is a need to educate the public on the risks of fentanyl and the need and availability of various methods of delivery of naloxone.Short Description: Caregiver insights on the risks of fentanyl and the need for naloxone to reverse opioid overdoses.Name of Sponsoring Organization(s): US WorldMeds