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Clinicopathological characteristics of patients with colorectal cancer lung metastasis under different conditions
After liver metastasis, lung is the second most common metastatic target organ of colorectal cancer (CRC). This study aimed to explore the clinicopathological features of lung metastasis of CRC.
A total of 1402 consecutive CRC patients with lung metastasis (LM) from November 2006 to August 2022 in Zhejiang Cancer Hospital were analyzed. The clinicopathological characteristics including sex, age, smoking, drinking, BMI, primary tumor location, pathological type, T, N, M stage, CEA, CA125, CA199 level, synchronous metastasis. Chi-square test and Kaplan–Meier analysis were performed to compare these factors.
Among the 1402 CRC LMs patients, 542 cases were complicated with liver metastasis, 511 cases with synchronous LM and 1152 cases with multiple lung metastases at initial diagnosis. Patients with solitary LM and those with multiple lung metastases had similar clinicopathological T, N, and M stages as well as CEA, CA125, and CA199 levels, but the solitary group' OS was significantly higher than that of the multiple group. Patients with synchronous liver metastasis had a worse prognosis than those with LM alone, and those with LM occurred after liver metastasis had a worse prognosis than those with lung metastasis first, then liver metastasis.
Our study indicated that CRC patients with LM after liver metastasis first and those with multiple lung metastases have poor prognosis, as well as those with synchronous liver and lung metastasis. Therefore, CRC patients with the above-mentioned characteristics should be closely followed up and actively intervened to improve the prognosis.
The authors.
This work was supported by Natural Science Foundation of Zhejiang Province (LY20H160004) and the Medical Health Science and Technology Project of Zhejiang Province (2021KY104, 2022KY628).
All authors have declared no conflicts of interest.
