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The frequency and pattern of metachronous recurrence after endoscopic submucosal dissection for dysplasias and adenocarcinoma of stomach
Metachronous recurrence incidences and risk factors following endoscopic submucosal dissection (ESD) for gastric adenocarcinoma and dysplasias were investigated.
Retrospective review of electronic medical records of patients who underwent gastric ESD at Yeouido St. Mary's Hospital.
A total of 190 subjects were enrolled for analysis during the study period. The mean age was 64.4-year-old and the male sex occupied 73.7%. The mean observation period following ESD was 3.45 years. The annual incidence rate of metachronous gastric neoplasms (MGN) was about 3.96%. The annual incidence rate was 5.36% for the LGD group, 6.47% for the HGD group, and 2.74% for the EGC group. MGN was more frequent in the dysplasia group than in the EGC group. (p-value < 0.05) For those with MGN development, the mean time interval from ESD to MGN was 4.1 (± 1.79) years. By using Kaplan Meier model, the estimated mean MGN free survival time was 9.97 years (95% CI: 8.53-11.40) The histological types of MGN were not related to the primary histology types.
MGN following ESD developed in 3.96% annually and MGN was more frequent in the dysplasia group. The histological types of MGN did not correlate with those of primary neoplasm.
The authors.
Has not received any funding.
All authors have declared no conflicts of interest.
