Poster P-383

Analysis of microsatellite and RAS/RAF status in Tunisian colorectal cancer series

Douik

Sahraoui

Doghri

Charfi

Letaief-Ksontini

Mrad

University of Tunis El Manar; Faculté de Médecine de Tunis; Institut Salah Azaiez; Department of Medical oncology, Tunis, Tunisia

Background

Therapeutic strategies for colo-rectal relies on several parameters among which microsatellite (MS) and RAS/RAF status have important value. The aim of our study was to analyze combined MS and RAS/RAF status in colorectal carcinoma (CCR).

Methods

We study a series of 73 cases of CCR with nodal/visceral metastasis. MS status was determined by immunohistochemistry. Molecular RAS/RAF testing was performed by the RT-PCR automatized Idylla system.

Results

67 cases were MS-proficient; among which 38 cases were RAS/RAF mutated : 30 cases were KRAS mutated, 4 were NRAS mutated and 4 BRAF mutated. Six patients were MS-deficient among which 4 cases were rectal KRAS mutated carcinoma, the 2 remaining cases were colic RAS/RAF wild type cases.

Conclusions

Our study found that MSI/RAS/RAF mutated status is rare (9.5%) meanwhile both MSS and RAS/RAF wild cases, representing the worst prognostic group, represent 40% of the cases.

Legal entity responsible for the study

The authors.

Funding

Has not received any funding.

Disclosure

All authors have declared no conflicts of interest.

Publisher

Elsevier Ltd

Source Journal

Annals of Oncology

E ISSN 1569-8041 ISSN 0923-7534

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