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Poster
1574753
EEG Individual Alpha Frequencies May Improve Depression Symptoms in TMS Treatment
Psych Congress 2023
Background: Recent evidence suggests that personalizing transcranial magnetic stimulation (TMS) to a person’s individual alpha frequency (IAF) (8, 9, 10, or 11 Hz) may yield better outcomes. Our question is: does a person’s IAF predict outcome? Are some frequencies more likely to respond than others? Here we examine the different IAFs of patients with major depressive disorder (MDD) and the patients’ responses to TMS using the Beck’s Depression Inventory (BDI).
Methods: Retrospective chart review was undertaken of 69 outpatients with MDD. Subjects aged 18-71 completed a full course of at least 30 TMS treatments and initially received 10 Hz treatment to the left DLpfc (located by the BEAM protocol). Baseline IAF was determined by an initial resting-state, 5 minutes eyes-closed dry wireless EEG (Cognionics, San Diego). Patient BDI was administered as part of the routine intake and before the last TMS treatment.
Results: For subjects with a baseline IAF of 8, 9, 10, or 11 Hz, the percentage of patients who reported a decrease in BDI were 60%, 96%, 73%, and 75%, respectively. The mean decrease in BDI across all subjects was 14%.
Conclusions: The most significant improvements were in patients with an IAF of 9 Hz (23% decrease in BDI, p=
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