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Poster
2757090
Patient-reported depressive symptoms among individuals diagnosed with Major Depressive Disorder with and without prominent anhedonia using a real-world dataset
Abstract: Anhedonia is a core feature of major depressive disorder (MDD). However, little is known about its related symptom burden and its impact on patients’ clinical trajectory. This retrospective cohort study used the Patient Health Questionnaire 9-items (PHQ-9) to assess depression symptoms at baseline and over time among MDD patients with prominent anhedonia (MDD-ANH) and with no/low anhedonia (other-MDD). Newly diagnosed MDD patients with their first recorded PHQ-9 within one month of diagnosis (baseline score) were included. Data are from a real-world dataset of over 500,000 patients with MDD in the US with linked claims and electronic medical record data (OM1, Inc. Boston MA). Prominent anhedonia was defined as a score of ≥2 on item 1 (anhedonia) of the PHQ-9 among moderately to severely depressed patients (PHQ-9 total score of ≥10). Symptom burden and remission (defined as PHQ-9 total score
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