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Poster 2757112

Real-world Survey of Clinical Experience using Dexmedetomidine Sublingual Film for Acute Agitation in over 200 Adults with Schizophrenia or Bipolar Disorder

Sonja Hokett, PharmD, MS, MSc - Executive Director, Medical Managed Care & HEOR, BioXcel Therapeutics
Michael Hooks, PharmD, BCCP, FCCP - Consultant, BioXcel Therapeutics
Mae Kwong, PharmD - Sr. Director, Medical Managed Care & HEOR, BioXcel Therapeutics

Psych Congress Elevate 2024
Abstract: Purpose: Agitation treatment in patients with schizophrenia or bipolar disorder is challenging. Alpha-2 agonist, IGALMI™ DSF (dexmedetomidine sublingual film) reduces norepinephrine. Real-world survey data from over 200 DSF-treated patients reported in the absence of existing publications. Methods: Consolidated results from 2 surveys (one year apart) with 35 total questions sent to 80 clinicians from 30 institutions. Results: Twenty-two respondents treating over 200 patients with DSF in multiple clinical settings. Most important feature was targeted mechanism of action. Starting doses equally 180-mcg and 120-mcg with 33% multiple times weekly. Impaired patients treated, and most self-administered. Only 20% used agitation protocols and 10% severity assessment tools. No additional patient monitoring required by 92% of respondents. Patient response time

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