Research on endocannabinoids could uncover treatments for cocaine addiction

Researchers at the University at Buffalo Research Institute on Addictions and Stony Brook University will examine the role of a fatty acid binding protein in contributing to the effects of cocaine use on the brain. These findings could inform the eventual development of much-needed drug therapies to combat stimulant addiction.

A two-year grant from the National Institute on Drug Abuse (NIDA) will support this research, which builds on previous inquiry into the workings of the brain's endocannabinoid system. Endocannabinoids are naturally produced lipids that control functions such as stress, memory and addiction.

“We know that dysregulation in endocannabinoid signaling contributes to the development and persistence of addictive behaviors,” said Panayotis Thanos, PhD, a researcher at the University at Buffalo institute. “Therefore, understanding the various mechanisms of this system is required for a better understanding of the neurobiology of addiction-related disorders and the development of effective treatments.”