Extra Weight Associated With PsA Onset

A higher body mass index (BMI) is linked with a higher risk of psoriatic arthritis (PsA) onset in patients with psoriasis, according to research published online in the Journal of the American Academy of Dermatology.

“Several lifestyle and environmental factors are associated with PsA onset among patients with psoriasis,” the researchers reported.

The systematic review and meta-analysis investigated modifiable lifestyle and environmental factors associated with risk of PsA in 16 observational studies spanning 322,967 patients with psoriasis.
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For each kg/m² rise in BMI, the risk of PsA rose 6% in patients with psoriasis, according to the study. The odds ratio for PsA with obesity was 1.75 (95% CI, 1.42-2.16), and the odds ratio with overweight was 1.50 (95% CI, 1.08-2.09).

A history of physical trauma or fracture was also linked with increased risk of PsA in patients with psoriasis. The study reported a 1.33 odds ratio (95% CI, 1.16-1.54) with a history of physical trauma and 1.46 odds ratio (95% CI, 1.22-1.74) with a history of fracture.

No significant associations were found for alcohol consumption, smoking, female hormonal exposure, or psychological trauma with increased PsA risk.

“These findings indicate such risk may be modified with lifestyle changes or avoidance of physical trauma in people with psoriasis,” the researchers wrote.

—Jolynn Tumolo

Reference

Xie W, Huang H, Deng X, Gao D, Zhang Z. Modifiable lifestyle and environmental factors associated with onset of psoriatic arthritis in patients with psoriasis: a systematic review and meta-analysis of observational studies. J Am Acad Dermatol. Published online August 19, 2020 August 19. doi:10.1016/j.jaad.2020.08.060