Inflammatory Skin Diseases May Be Associated With Increased VTE Risk

Atopic dermatitis (AD), pemphigus, and pemphigoid are likely associated with an increased risk for venous thromboembolism (VTE), according to the findings of a recent study published in Archives of Dermatological Research.

“Patients with certain inflammatory skin diseases have multiple risk factors for [VTE],” the researchers said.

The study analyzed representative data from the 2002-2012 Nationwide Inpatient Sample to determine whether AD, psoriasis, pemphigus, pemphigoid, and hidradenitis suppurativa (HS) were associated with VTE. A total of 72,512,581 adults, including 1,389,292 with VTE, were included. The researchers used multivariable logistic regression models that included age, sex, insurance, household income, race/ethnicity, and hospitalizations records for inflammatory skin diseases to calculate adjusted odds ratios (OR).

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Analyses showed that hospitalizations for AD (adjusted OR 1.22; 95% CI, 1.17-1.27), pemphigus (adjusted OR 1.96; 95% CI 1.68-2.28), and pemphigoid (adjusted OR 1.64; 95% CI 1.47-1.83) were associated with VTE. “These associations remained significant in virtually all patient subsets, including males and females, different age groups, and those with and without long-term corticosteroid use,” the researchers said. They also noted that AD, pemphigus, and pemphigoid were each associated with both deep vein thrombosis and pulmonary embolus.

For all inflammatory skin diseases, VTE was associated with increased inpatient length of stay, cost of care, and mortality. In addition, they found that higher odds of hospitalizations with VTE were associated with AD, pemphigus, pemphigoid, and some subsets of patients with HS. However, both HS and psoriasis were not consistently associated with VTE, they noted.

“Patients with these inflammatory skin diseases may benefit from increased screening and prevention of VTE,” the researchers concluded.

Reference

Shaheen MS, Silverberg JI. Association of inflammatory skin diseases with venous thromboembolism in US adults. Arch Dermatol Res. Published online July 8, 2020. doi:10.1007/s00403-020-02099-6