Hypovitaminosis D Prevalent in Patients With Psoriasis With and Without Psoriatic Arthritis

According to a study published in the Sao Paulo Medical Journal, patients with psoriatic disease with or without psoriatic arthritis (PsA), have highly prevalent hypovitaminosis D.

Researchers conducted a retrospective cross-sectional study that consisted of 300 patients with psoriasis, with and without PsA, and independent predictors of serum 25(OH)D levels in an outpatient clinic to determine the prevalence of hypovitaminosis D. Additionally, they reviewed the demographics and clinical data (consisting of Psoriasis Area and Severity Index [PASI] score, family history, age at onset, disease duration, and the presence of PsA according to Classification Criteria for Psoriatic Arthritis), skin phototype, and season of the year.

The study found that hypovitaminosis D was highly prevalent in patients with psoriasis with and without PsA. Also, there was an inverse correlation between the PASI score and vitamin D. Multivariate regression revealed that hypovitaminosis D was associated with disease severity, season, and phototype. Finally, this was confirmed by binary logistic regression between PASI scores and vitamin D deficiency.

“Season and skin phototype were associated with 25(OH)D levels. An inverse association between PASI [scores] and serum 25(OH)D levels was established,” the authors concluded.

Reference
Gamonal SBL, Gamonal ACC, Marques NCV, Brandão MAF, Raposo NRB. Is vitamin D status relevant to psoriasis and psoriatic arthritis? A retrospective cross-sectional study. Sao Paulo Med J. Published online September 6, 2022. doi:10.1590/1516-3180.2022.0216.R1.01072022