P057 Measuring patient-reported outcomes in Crohn’s disease patients during the outbreak of COVID-19 Parra Rogerio1, Feitosa Marley1, Ferreira Sandro1, Camargo Hugo1, Rocha José Joaquim1, Féres Omar1 1 Ribeirão Preto Medical School, University of São

P057  Measuring patient-reported outcomes in Crohn’s disease patients during the outbreak of COVID-19

Parra Rogerio1, Feitosa Marley1, Ferreira Sandro1, Camargo Hugo1, Rocha José Joaquim1, Féres Omar1
1 Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil

BACKGROUND: There are no data regarding the application of Patient-Reported Outcome (PRO) measures under the COVID-19 pandemic. The aim of the present study was to use a specific PRO measuring tool in CD patients during the COVID-19 pandemic.

METHODS: We interviewed 67 consecutive CD patients during the COVID-19 quarantine. We measured PROs using an adapted questionnaire that consists of a structured questionnaire evaluating two major domains: “symptoms” and “impacts”. In the “symptoms” domain, four sub-domains were evaluated, namely: “gastrointestinal”, “pain and discomfort”, “nutrition-related” and “energy-related”. In the “impacts” domain, six sub-domains were evaluated: “emotional”, “daily performance”, “lifestyle and activities”, “social functioning” and “dietary”.

RESULTS: A total of 67 patients were interviewed. Mean age was 43.0 ± 14.7 years, 58.2% of patients were male. Mean disease duration was 12.4±9.1years, a history of perianal disease was present in 49.3% of patients, and 41.8% had previous bowel resection. There were no statistical differences in any of the four symptoms subdomains [“gastrointestinal” (P=0.51), “pain and discomfort” (P=0.08), “nutritional-related” (P=0.97), and “energy-related” (P=0.70)] when we compared active CD and patients in deep remission. There were no statistical differences in 4 of 6 subdomains [“daily performance” (P=0.13), “lifestyle and activities” (P=0.89), “social functioning” (P=0.97), “dietary” (P=0.34)]. Two out of 6 “impacts” sub-domain were significantly reduced in patients with clinical activity compared to patients in deep remission [Emotional (P=0.04) and additional QoL (P=0.01)].

CONCLUSION(S): The application of PRO measures in IBD patients demonstrated a negative impact on the emotional aspects and QoL quality of life during COVID-19 outbreak.

Keywords: Crohn’s disease; inflammatory bowel diseases; patient reported outcomes measures; quality of life; disease outbreaks.