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A Fresh Look at Incidence and Prevalence of EoE
A recent analysis showed that the incidence and prevalence of eosinophilic esophagitis (EoE) have increased substantially since diagnostic criteria were expanded in 2018, researchers reported in Clinical Gastroenterology and Heptalogy.
“We aimed to describe global, regional, and national trends in the incidence and prevalence of EoE from 1976 to 2022 and analyze their associations with geographic, demographic, and social factors through a systematic review,” the authors explained.
Using the PubMed/MEDLINE, Embase, CINAHL, Google Scholar, and Cochrane databases, the investigators identified studies reporting EoE rates through December 20, 2022, and “calculated the global incidence and prevalence of EoE using pooled estimates with 95% confidence intervals (CIs) and performed subgroup analysis based on age, sex, race, geographical area, World Bank income group, and diagnostic criteria of EoE.”
The team found 40 studies that met the eligibility criteria, which included more than 288 million participants and 147,668 patients with EoE. “The global pooled incidence and prevalence of EoE were 5.31 cases per 100,000 inhabitant-years (95% CI, 3.98–6.63; number of studies, 27; sample population, 42,191,506) and 40.04 cases per 100,000 inhabitant-years (95% CI, 31.10–48.98; number of studies, 20; sample population, 30,467,177), respectively,” the authors stated. “The pooled incidence of EoE was higher in high-income countries (vs low- or middle-income countries), males, and North America (vs Europe and Asia).”
The global prevalence of EoE gradually increased from 1976 to 2022 (1976–2001; 8.18; 95% CI, 3.67–12.69 vs 2017–2022; 74.42; 95% CI, 39.66–109.19 cases per 100,000 inhabitant-years), they added.
“The incidence and prevalence of EoE have increased substantially and vary widely across the world. Further research is needed to evaluate the incidence and prevalence of EoE in Asia, South America, and Africa,” the investigators concluded.
Reference:
Hahn JW, Lee K, Shin JI, et al. Global incidence and prevalence of eosinophilic esophagitis, 1976–2022: a systematic review and meta-analysis. Clin Gastroenterol Hepatol. Published online: June 16, 2023.
DOI: https://doi.org/10.1016/j.cgh.2023.06.005
