Efficacy and Safety of Intraarterial Chemotherapy in Locally Aggressive Breast Cancers: A 10-Year Literature Review

Brendan Ryu discusses his CIO2023 abstract, "CIO 2023-23 Efficacy and Safety of Intraarterial Chemotherapy in Locally Aggressive Breast Cancers: A 10-Year Literature Review ."

Efficacy and Safety of Intraarterial Chemotherapy in Locally Aggressive Breast Cancers: A 10-Year Literature Review from HMP on Vimeo.

Hi, my name is Brendan Ryu. I'm an MS4 at the Zucker School of Medicine at Hofstra Northwell. I'm a Pioneer Interventional in Diagnostic Radiology this year, and I'm really excited to share our project. This was with the help of Dr. Mustafa Al-Rubaye down at Mott Cancer Center. He used to be at Northwell and was a great mentor.

We did a 10-year literature review. We explored the use of intra-arterial chemotherapy in the treatment of locally aggressive breast cancer, which is a very challenging condition and it has limited treatment options. Intra-arterial chemotherapy, we can super-select certain arteries that are feeding the cancer so that we can reduce systemic side effects and provide better treatment and more efficacious treatment to an actual tumor.

We were able to identify 8 studies that involved 356 patients and it revealed very promising results. The overall objective response rate to IAC was an impressive 80% with added benefits such as increased surgical options and shorter time to surgery for the patient. However, it is important to note that there were a lot of side effects.

Around 17% of the patients had nausea and vomiting, and around 6% of the patients had skin ulceration, depending on the collaterals from the feeding artery. The study limitations include retrospective designs, lack of randomization, and small sample sizes. So we do need more randomized control trials perspective to be able to identify if IAC is better than standard of care. We also present a case that was done at Northwell. It involved a 79-year-old woman with breast cancer, status post lumpectomy. You can see here that the IMA was super selected and their feeding arteries branching off the IMA. After IAC, the IMA was preserved and arteriography showed decreased tumor blush.

Thank you.