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![OLN](/themes/custom/hmpnet/img/biological-pathway-reviews.png)
G protein-coupled receptor class C group 5 member D (GPRC5D) is a gene expressed in the hair follicle and malignant bone marrow plasma cells.1 G protein-coupled receptor proteins are cell surface receptors located in the plasma membrane. Activation of the protein occurs when it binds to an external signaling molecule, which causes a conformational change and triggers an interaction between the protein and an available G protein.2
Understanding the Role of GPRC5D
Expression Percentages per Cancer Type
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GPRC5D Targeting Anticancer Drugs
GPRC5D is a promising immunotherapeutic target, particularly in patients with multiple myeloma. This table outlines therapies targeting GPRC5D in the pipeline.
![Table icon](/themes/custom/hmpnet/img/table-icon.png)
GPRC5D Targeting Anticancer Drugs in the Pipeline |
|
Generic Drug Name |
Potential Indications |
Talquetamab1 |
A first-in-class investigational bispecific antibody targeting both GPRC5D and CD3 being evaluated for the treatment of patients with relapsed or refractory multiple myeloma. |
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