Acute Myeloid Leukemia
NTRK alteration has been reported in low frequency in patients with AML.4
Brain Cancer
In <5% of patients with gliomas, NTRK fusions have been reported.8
CNS Tumors
NTRK fusions have been recognized in pediatric and adult patients with CNS tumors, such as gliomas.1,6
Colorectal Cancer
NTRK fusions occur in less than 1% colorectal cancer cases.2
Gastrointestinal Stromal Tumor
In up to 75% of patients with GIST, NTRK gene fusion has been identified.8
Infantile Fibrosarcoma
NTRK3 fusions are found in more than 80% of congenital infantile fibrosarcoma cases, noting that this type of tumor is rare and represents less than 1% of pediatric cancer cases.1,2
Inflammatory Tumors
NTRK3 gene fusions have been noted in adolescent and adult patients with inflammatory myofibroblast tumors.1,6
Lung Cancer
Gene fusions occur in up to 1% of non-small-cell lung cancer cases.1
Melanoma
Translocations and gene NTRK fusions have been noted in spitzoid melanoma tumors in less that 1% of cases.1,6
Secretory Breast Cancer
Noted as one of the rarest forms of breast cancer, secretory breast cancer involves high rates of NTRK gene fusion.1,2
Soft-Tissue Sarcomas
NTRK fusions are rare but have been observed in soft-tissue sarcoma patients.1,6
Thyroid Cancer
Rearrangement of NTRK1 in papillary thyroid carcinoma, the most common form of thyroid cancer, ranges from less than 5 to 25% of cases.NTRK fusions occur with an intermediate frequency in pediatric thyroid cancers. Differentiated and papillary thyroid tumors have a 22 to 26% frequency of NTRK fusions.1,2
