Conference Coverage

Study Suggests Retifanlimab Plus Chemotherapy as New Standard of Care for Locally Recurrent or Metastatic Anal Cancer

09/16/2024

Sheela Rao, MBBS, MD, The Royal Marsden Hospital, London, England, discusses results from the phase 3 POD1UM-303/InterAACT 2 study which randomized patients with inoperable, locally recurrent or metastatic squamous cell carcinoma of the anal canal (SCAC) to receive either retifanlimab plus standard carboplatin-paclitaxel or placebo plus standard carboplatin-paclitaxel.

Results demonstrated encouraging efficacy and favorable risk-to-benefit ratio for the addition of retifanlimab to carboplatin-paclitaxel, suggesting a potential new standard of care regimen for patients with SCAC.

Dr Rao presented these results at the 2024 European Society of Medical Oncology (ESMO) Congress in Barcelona, Spain.

Source:

Rao S, Samalin-Scalzi E, Evesque L, et al. POD1UM-303/InterAACT 2: Phase III study of retifanlimab with carboplatin-paclitaxel (c-p) in patients (pts) with inoperable locally recurrent or metastatic squamous cell carcinoma of the anal canal (SCAC) not previously treated with systemic chemotherapy (chemo). Presented at 2024 ESMO Congress. September 13-17, 2024. Abstract LBA2

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Any views and opinions expressed are those of the author(s) and/or participants and do not necessarily reflect the views, policy, or position of Oncology Learning Network or HMP Global, their employees, and affiliates.

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