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Niraparib Plus Abiraterone Acetate and Prednisone for Metastatic Castration-Resistant Prostate Cancer With HRR Gene Alterations
Final Analysis of the Phase 3 MAGNITUDE Trial
Final Analysis of the Phase 3 MAGNITUDE Trial
Elena Castro, MD, PhD, Hospital Universitario 12 de Octubre, Madrid, Spain, discusses the final analysis of the phase 3 MAGNITUDE trial. This study compared niraparib plus abiraterone acetate and prednisone (AAP) with placebo plus AAP among patients with metastatic castration-resistant prostate cancer (CRPC) and homologous recombination repair (HRR) gene alterations.
In this trial, Dr Castro stated, “we have seen an overall survival benefit from the combination [of abiraterone plus niraparib] for patients with BRCA1 and BRCA2 mutations." She added, "We should make the effort of identifying all our patients with BRCA mutations to offer them treatment with a PARP inhibitor as soon as possible."
These results were first presented by Kim Nguyen Chi, MD, BC Cancer and Vancouver Prostate Centre at University of British Columbia, Vancouver, British Columbia, Canada, at the 2023 European Society for Medical Oncology Annual Congress in Madrid, Spain.
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Chi KNN, Castro E, Attard G, et al. Niraparib (NIRA) with abiraterone acetate plus prednisone (AAP) as first-line (1L) therapy in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC) and homologous recombination repair (HRR) gene alterations: Three-year update and final analysis (FA) of MAGNITUDE. Presented at 2023 ESMO Annual Congress; October 20-24, 2023; Madrid, Spain. LBA85