ADVERTISEMENT
Understanding the Evidence on Topical Oxygen Therapy for Diabetic Foot Ulcers Advances
Understanding the Evidence on Topical Oxygen Therapy for Diabetic Foot Ulcers
Oxygen is vital for wound healing, as healthy tissue requires appropriate levels of oxygen, along with other factors, to survive, thrive, and regenerate.1 Wounds and tissue injuries result in local hypoxia, likely in part from vascular disruption and elevated oxygen consumption.2 This hypoxic state should initiate wound healing, but if it becomes chronic, there can be delays in neovascularization and an impaired cellular response.3
Topical oxygen therapy is one option that addresses this type of hypoxia. In this modality, oxygen is directly delivered to the wound bed, and has revealed benefits related to antibacterial action, epithelial migration, and collagen production.4 Several recent reviews, meta-analyses, and randomized controlled trials are yielding promising results for diabetic foot ulcers.5-10
In this program, Matthew Regulski, DPM, dives into the latest research to share what clinicians should know about this treatment option in the treatment of diabetic foot ulcers.
Topical Oxygen Therapy: The Latest Evidence and Insights from HMP on Vimeo. Click here for a transcript of this video.
Topical Oxygen Therapy: What Does the Literature Say? from HMP on Vimeo. Click here for a transcript of this video.
Topical Oxygen Therapy: Another Look at the Evidence from HMP on Vimeo. Click here for a transcript of this video.
References
1. Kimmel HM, Grant A, Ditata J. The presence of oxygen in wound healing. Wounds. 2016;28(8):264-270.
2. Ruthenborg RJ, Ban JJ, Wazir A, Takeda N, Kim JW. Regulation of wound healing and fibrosis by hypoxia and hypoxia‐inducible factor‐1. Mol Cells. 2014;37(9):637‐643.
3. Catrina SB, Zheng X. Disturbed hypoxic responses as a pathogenic mechanism of diabetic foot ulcers. Diabetes Metab Res Rev. 2016;32(Suppl 1):179‐185.
4. Kaufman H, Gurevich M, Tamir E, Keren E, Alexander L, Hayes P. Topical oxygen therapy stimulates healing in difficult, chronic wounds: a tertiary centre experience. J Wound Care. 2018;27(7):426‐433.
5. Sun X-K, Li R, Yang X-L, Yuan L. Efficacy and safety of topical oxygen therapy for diabetic foot ulcers: an updated systematic review and meta-analysis. Int Wound J. 2022;19(8):2200-2209.
6. Carter MJ, Frykberg RG, Oropallo A, et al. Efficacy of topical wound oxygen therapy in healing chronic diabetic foot ulcers: systematic review and meta-analysis. Adv Wound Care (New Rochelle). 2023;12(4):177-186.
7. Connaghan F, Avsar P, Patton D, O’Connor T, Moore Z. Impact of topical oxygen therapy on diabetic foot ulcer healing rates: a systematic review. J Wound Care. 2021;30(10):823-829.
8. Yellin JI, Gaebler JA, Zhou FF, et al. Reduced hospitalizations and amputations in patients with diabetic foot ulcers treated with cyclical pressurized topical wound oxygen therapy: real-world outcomes. Adv Wound Care (New Rochelle). 2022:11(12):657-665.
9. Frykberg RG, Franks PJ, Edmonds M, et al. A multinational, multicenter, randomized, double-blinded, placebo-controlled trial to evaluate the efficacy of cyclical topical wound oxygen (TWO2) therapy in the treatment of diabetic foot ulcers: the TWO2 study. Diabetes Care. 2020;43:616-624.
10. Nataraj M, Maiya AG, Karkada G, et al. Application of topical oxygen therapy in healing dynamics of diabetic foot ulcers - a systematic review. Rev Diabet Stud. 2019;15:74-82.
Quiz Maker - powered by Riddle
