Hidradenitis suppurativa (HS) could be a potential independent risk factor for various cardiovascular diseases, according to the findings of a recent study that was presented at the American Academy of Dermatology 2019 Annual Meeting in Washington, DC.
“Chronic inflammation underlies the pathophysiology in both the development of atherosclerotic disease and HS. Therefore, the increased inflammatory burned in HS potentially places these patients at a higher risk of developing poor cardiovascular outcomes,” the researchers stated.
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To determine whether HS was associated with cardiovascular diseases, the researchers identified 4914 patients with HS, 4641 patients with psoriasis, and 23,266 healthy controls at Duke University Medical Center. They calculated and compared the odds of stroke, coronary artery disease (CAD), peripheral artery disease (PAD), and heart failure among all 3 cohorts, and adjusted for gender, race, age, hypertension, hyperlipidemia, and diabetes, as well as body mass index and smoking status.
After adjusting for demographic risk factors, the researcher found a significantly increased odds for CAD, PAD, and stroke among individuals with HS compared with controls. While the odds for heart failure was higher among individuals with HS, it was not significant compared with controls.
Multivariate analysis showed increased odds for stroke, CAD, and PAD among individuals with HS compared with those with psoriasis. However, these findings were not statistically significant.
“Our current results show that the association between HS and cardiovascular diseases persists, despite adjusting for [cardiovascular risk factors],” the researchers concluded. “Our results should be informative to providers caring for patients with HS. Cardiovascular disease is the leading cause of death in the US. Providers should be vigilant about mitigating risk factors and educating HS patients about the risks associated with cardiovascular comorbidity.”
Reference
Ward RA, Kakaati R, Liu B, Green C. Hidradenitis suppurative is associated with increased odds of stroke, coronary artery disease, heart failure, and PAD: A population-based analysis in the United States. Presented at: 2019 American Academy of Dermatology Annual Meeting; March 1-5, 2019; Washington, DC.
