Hyaluronic Acid Filler Injections for Nonsurgical Facial Aesthetics

A systematic review of high-level evidence studies published in Aesthetic Plastic Surgery provides valuable insights into the spectrum of adverse events associated with hyaluronic acid (HA) filler injections for nonsurgical facial aesthetics.

Conducted in accordance with Cochrane review standards, this systematic review analyzed 48 high-level evidence studies focusing on HA dermal fillers and their associated complications. The review aimed to classify adverse events based on their nature, severity, and potential causative factors, shedding light on the nuances of HA filler complications.

Adverse events were categorized into 3 main groups: expected reactions, product- or technique-related adverse events, and severe adverse events. Most adverse events observed were transient injection site reactions, which typically resolved spontaneously over time. However, specific HA filler formulations and injection techniques were found to influence the occurrence and severity of adverse events.

Although most adverse events were mild to moderate in nature, severe complications were rare but noteworthy, often requiring active medical intervention and persisting for extended periods. These adverse events included severe edema, angioedema, and other rare complications.

“HA dermal fillers are generally safe and effective, with most adverse events being transient and mild to moderate in severity,” concluded study authors. “Severe adverse events, although rare, do occur and are generally non-treatment related. Informed consent, patient education, and professional training are crucial for safe and successful outcomes.”

Reference

Kyriazidis I, Spyropoulou GA, Zambacos G, et al. Adverse events associated with hyaluronic acid filler injection for non-surgical facial aesthetics: a systematic review of high level of evidence studies. Aesthetic Plast Surg. Published online ahead of print August 10, 2023. doi:10.1007/s00266-023-03465-1