Patients With Pediatric Granuloma Annulare Often Present With Asthma and Atopy

A clinical and histopathologic evaluation should be performed in patients with pediatric granuloma annulare (GA), according to a study published in Dermatology Practical & Conceptual.

Researchers aimed to perform a clinical and histopathologic evaluation of 41 pediatric GA cases in a retrospective study. The study was conducted at a single-center tertiary hospital. Demographic, clinical, and pathologic features of pediatric GA cases were recorded.

A total of 66% of the participants were female and the mean age was 3.8 ± 2.6 years. The mean lesion duration was 7.5 ± 10.3 months. Localized involvement was observed in 78% of the patients, whereas the remaining 22% was generalized. A total of 30% of the patients had asthma, 71% had an interstitial infiltrate pattern, and 29% had a palisadic infiltrate pattern. Patients with a palisadic pattern had higher generalized distribution, trunk involvement, and concomitant disease.

“Atopy and asthma should be questioned in pediatric GA cases,” concluded the study authors. “There are differences between involvement, distribution, concomitant disease, and histopathological patterns, which may indicate differences in pathogenesis,” they added.

Reference
Aksu AEK, Erdil Dİ, Baş VM, Türk CB, Leblebici C, Tellal ES. Clinical and histopathological evaluation of forty-one cases of pediatric granuloma annulare. Dermatol Pract Concept. Published online ahead of print January 12, 2023. doi:10.5826/dpc.1301a113