Systemic Immunity-Inflammation Index Associated With Psoriasis

According to a recent study published in Frontiers in Immunology, a systemic immune-inflammatory index (SII) higher than 479.15 × 109/L is positively associated with a high risk of psoriasis among outpatient adults in the United States.

Researchers aimed to assess the association between the SII and psoriasis among US adult outpatients. They utilized data from the National Health and Nutrition Examination Survey (NHANES) spanning 2003 to 2006 and 2009 to 2014, involving 16,831 adults aged 20 to 59 years. Sample-weighted logistic regression and stratified analysis of subgroups were employed.

Among the participants, 8801 were women and 8030 were men, with a psoriasis prevalence rate of 3.0%. After adjusting for confounding factors, the study found a positive association between an SII higher than 479.15 × 109/L and an increased risk of psoriasis. Subgroup analyses and interaction testing revealed that age, sex, alcohol drinking status, marital status, and body mass index did not significantly influence this positive association.

“To the best of our knowledge, this is the first cross-sectional study using NHANES data focused on the risk of higher SII on psoriasis among outpatient US adults. The outcomes of this cross-sectional serve to supplement previous research, indicating a need for larger-scale prospective cohorts for further validation,” the authors concluded.

Reference
Ding Q, Li X, Lin L, et al. Association between systemic immunity-inflammation index and psoriasis among outpatient US adults. Front Immunol. Published online June 4, 2024. doi:10.3389/fimmu.2024.1368727