Skip to main content

Advertisement

Advertisement

ADVERTISEMENT

News

Threshold of Clinically Meaningful Within-Patient Changes in POEM and CDLQI in Children 6 to 11 Years of Age With Severe Atopic Dermatitis Defined

Lisa Kuhns, PhD

A recent study published in Dermatology and Therapy defines clinically meaningful within-patient changes in Patient-Oriented Eczema Measure (POEM) and Children’s Dermatology Life Quality Index (CDLQI) in children with severe atopic dermatitis (AD).

“For adults with AD, a responder threshold for clinically meaningful change of 4 points has been established for both POEM and Dermatology Life Quality Index (DLQI),” explained the study authors. “However, there is currently no validated responder threshold for clinically meaningful change in these instruments for children with AD (aged 6-11 years),” they continued.

Researchers used data from the LIBERTY AD PEDS phase 3 randomized, double-blind, placebo-controlled trial of dupilumab in children aged 6 to 11 years with severe AD to define the threshold for within-patient meaningful change in POEM and CDLQI scores.

Results from the LIBERTY AD PEDS data indicate that a reasonable range of threshold estimates to define meaningful improvement and within-patient change in POEM score of 6 to 8 points. CDLQI analyses indicate a reasonable range and within-patient change in score of 6 to 7 points.

“In children with severe AD, an appropriate minimum threshold of clinically meaningful within-patient change was estimated as 6 points for both the POEM and CDLQI scores,” concluded the study authors.

Reference
Simpson EL, de Bruin-Weller M, Bansal A, et al. Definition of clinically meaningful within-patient changes in POEM and CDLQI in children 6 to 11 years of age with severe atopic dermatitis. Dermatol Ther (Heidelb). Published online May 27, 2021. doi:10.1007/s13555-021-00543-7

Advertisement

Advertisement

Advertisement