Tumor Necrosis Factor-Alpha Polymorphisms and Risk of Psoriasis

According to a study published in Heliyon, A allele and GA and GG genotypes of -238 G/A rs361525 polymorphism and T allele and TT and CT genotypes of -857C/T rs1799724 polymorphism were related to increased risks in psoriasis cases.

Researchers aimed to investigate the association between tumor necrosis factor-alpha (TNF-α) polymorphisms (specifically rs361525, rs1800629, rs1799724, 1800630, and rs1799964) and the risk of psoriasis. Psoriasis is an immune-related disease influenced by genetic factors, and cytokines play a crucial role in its incidence and prevalence. They conducted a comprehensive search of 4 databases to identify relevant studies that reported the distribution of TNF-α polymorphisms in psoriasis cases compared to control groups. They included 36 articles comprising 71 studies in the meta-analysis, focusing on the mentioned polymorphisms.

The findings revealed significant associations between specific TNF-α polymorphisms and psoriasis risk. For the rs361525 polymorphism, the pooled odds ratios were statistically significant across various genetic models, indicating an increased risk in psoriasis cases. Similarly, the rs1799724 polymorphism showed significant associations in allelic, homozygous, heterozygous, dominant, and recessive models. However, the researchers observed that ethnicity, psoriasis type, and sample size influenced the pooled results for certain polymorphisms (rs361525, rs1800629, and rs1799724).

“Well-designed studies (with no deviation from HWE in controls) with more cases are recommended in the future,” the authors concluded.

Reference
Sadafi S, Ebrahimi A, Sadeghi M, Emami Aleagha O. Association between tumor necrosis factor-alpha polymorphisms (rs361525, rs1800629, rs1799724, 1800630, and rs1799964) and risk of psoriasis in studies following Hardy-Weinberg equilibrium: a systematic review and meta-analysis. Heliyon. Published online June 22, 2023. doi:10.1016/j.heliyon.2023.e17552