Reconstruction of Post-Mohs Surgical Wounds Using a Novel Synthetic Nanofiber Matrix*

Healing post-Mohs surgical wounds can be challenging, depending on the size, location, depth, and prevalence of exposed structures [1]. Additionally, achieving an aesthetic outcome may be an added expectation, especially for facial lesions [2]. Here, we explore the use of a novel synthetic nanofiber matrix* after Mohs micrographic surgery in order to achieve desired results.

In this case series, 4 patients with nonmelanoma skin cancers on the auricular helix area underwent Mohs micrographic surgery at the South Carolina Skin Cancer center. The synthetic nanofiber matrix* was then applied to the prepared Mohs surgical defect, anchored in place using sutures, and covered with a dressing. The wounds were evaluated regularly for healing progress, and additional synthetic nanofiber matrix* was applied as needed during follow-up.

Patients included in this study were mainly male (80%) with an average age of 78 years and had major comorbidities including hypertension, congestive heart failure, cerebrovascular accident, and exposed perichondrium and cartilage. Wounds were treated with an average of 1.25 ± 0.50 applications of synthetic nanofiber matrix*. Wounds had an initial average size of 11.8 cm2. All wounds completely healed in 7.9 ± 4.2 weeks with excellent aesthetic results, no scar formation, and the absence of any skin deformity. In cases with exposed structures (cartilage and perichondrium), the synthetic nanofiber material promoted complete closure and healing. Across all cases, no complications were reported.

Treatment using a synthetic nanofiber matrix* led to complete wound healing in all patients with no reported complications. This study shows that the synthetic nanofiber matrix* is a viable option for the reconstruction of post-Mohs surgical defects.

Trademarked Items (if applicable): *Restrata®, Acera Surgical, Inc., St Louis, MO

References (if applicable): 1. Oganesyan, Gagik, et al. "Efficacy and complication rates of Full‐Thickness skin graft repair of lower extremity wounds after mohs micrographic surgery." Dermatologic Surgery 39.9 (2013): 1334-1339.
2. Faulhaber, Joerg, et al. "Functional and aesthetic reconstruction of full‐thickness defects of the lower lip after tumor resection: analysis of 59 cases and discussion of a surgical approach." Dermatologic surgery 36.6 (2010): 859-867.