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Long-term Follow-up in Restoring Soft Tissue Deficits with A Novel Human Adipose Allograft Matrix*
Speaker: Matthew Regulski, DPM FFPM RCPS (Glasgow)
Introduction
Lower extremity wounds affect up to 13% of the population with increasing prevalence due to factors such as smoking, diabetes, and hypertension. Unfortunately, after the wound is healed, re-ulceration is common, with approximately 40% recurrent ulcers within 1 year. A novel adipose allograft matrix (AAM) can help support endogenous fat pad restoration and its natural cushion-ing ability over high pressure points and/or bony prominence. This case study presents three long-term cases treated with AAM that did not re-ulcer, which has allowed patients to continue with their daily activities.
Method
We present 3 cases with underlying co-morbidities and soft tissue deficits on the lower extremities. All the patients had gone through previous treatments such as debridement and rotational flap closure without any resolution. AAM was inject-ed subcutaneously in all 3 cases to fill in soft tissue defects and provide a cushion support to the wound bed. Patients were fitted for custom molded diabetic shoes and monitored post-treatment.
Results
All 3 patients did not re-ulcer after AAM application, with long-term follow-up so far at 1 year 9 months up to 3 years. No adverse events were observed through-out this study. Routine monitoring of the patients, inspection of their feet and overall wound management was diligently continued.
Conclusion
These cases demonstrate that AAM can support the fat pad and cushioning ability in soft tissue defects and some re-ulceration prevention long-term. This ultimately allows patients to continue their daily activities.
