Alexander Higa, MA

Evaluation of an In-vivo Efficacy of Various Concentrations of PVP/NO-based Formulations on Infected Wounds with Pseudomonas Aeruginosa ATCC 27312 and Healing Process Using a Superficial Partial Thickness Porcine Wound Model

Background: Nitric Oxide (NO)-based products are known to have antimicrobial and antibiofilm properties. Purpose: The goal of this study was to determine the effects of various...

Joel Gil , BS, MS;

Jose Valdes , RN;

Michael Solis , MBA;

Stephen C. Davis , BS, MS;

Alexander Higa , MA;

Fernando Parajon ;

Jie Li , MD, PhD;

02/09/2019

Original Research

Effect of Mechanical Debridement and Irrigation With Hypochlorous Acid Wound Management Solution on Methicillin-resistant Staphylococcus aureus Contamination and Healing Deep Dermal Wounds in a Porcine Model

08/03/2021

Jose Valdes , RN;

Joel Gil , BS, MS;

Alexander Higa , MA;

Michael Solis , MBA;

Jie Li , MD, PhD;

Colin Simms , MS;

Stephen C. Davis , BS, MS;

08/03/2021

Wound Management & Prevention

TWO Negative Pressure Wound Therapy (NPWT) System Abilities are Compared for Accurate Pressure Delivery and Efficient Fluid Removal, Is there a Difference?

INTRODUCTION: Negative pressure wound therapy (NPWT) systems must have certain technical capabilities to effectively deliver therapy. The International Consensus Review for NPWT Systems, ...

Jie Li , MD, PhD;

Joel Gil , BS, MS;

Alexander Higa , MA;

Rey V. Paglinawan , BS;

Aurelie Boulzemat , PhD;

Stephen C. Davis , BS, MS;

Bela Kelety , PhD;

David Goldsmith , PhD;

05/26/2022

Extended Antibacterial Activity of Multi-Action Wound Treatment

Introduction: The aim of the study was to assess the antibacterial activity of a novel multi-action treatment (MAT*) over 24-hour and seven-day periods, reflecting the possible length of ...

Stephen C. Davis , BS, MS;

David Farrar , BSc;

Alexander Higa , MA;

Michael Solis , MBA;

Steven J. Kavros , DPM, MAPWCA, FACCWS;

Phillip Frost ;

05/26/2022

Functional Properties of a Purified Reconstituted Bilayer Matrix Design Support Natural Wound Healing Activities

Background: Advanced biomaterial engineering has produced unique wound care matrices using various tissue sources and processing methods. Source and process may impact the ability of the ...

Stephen C. Davis , BS, MS;

Alexander Higa , MA;

David G. Armstrong , DPM, MD, PhD, MSc;

Michael Solis , MBA;

Phillip Frost ;

05/26/2022

Determination of the Debridement Effects of an Enzymatic Hydrogel on Deep Dermal Wounds using a Porcine Model

Establishing and maintaining a pathogen-free environment of acute and chronic wounds is vital for optimum healing.1-4 One of the first steps in preventing biofilm consists of debriding th...

Joel Gil , BS, MS;

Nina Bionda , PhD;

Stephen C. Davis , BS, MS;

Mehmet Ozturk , PhD;

Tricia Conti , MS;

Kimberly Jaskula , MS;

Sara Ryan , BS;

Alexander Higa , MA;

Jillian Patterson , BS;

05/26/2022

In-vitro Study Evaluating the Sustained Released Effects of Antimicrobial Products Against Methicillin-resistant Staphylococcus Aureus (MRSA)

Background: Wound matrices are designed to stimulate cell proliferation and new tissue growth. Purpose: This study examines the sustained release of a wound matrix that contain...

Michael Solis , MBA;

Stephen C. Davis , BS, MS;

Alexander Higa , MA;

Joel Gil , BS, MS;

Jose Valdes , RN;

07/29/2019

Effectiveness of Pyruvate Dehydrogenase Enzyme (PDH) in the Dispersion of Established Biofilms of Pseudomonas Aeruginosa (ATCC 27312) Using a Deep Partial Thickness Porcine Wound Model

Background: Pseudomonas aeruginosa (PA) is a gram-negative microorganism with a high capability of forming biofilm. New technologies have been developed to either prevent biofilm fro...

Amber Doiron ;

Joel Gil , BS, MS;

Alexander Higa , MA;

Jose Valdes , RN;

Michael Solis , MBA;

Stephen C. Davis , BS, MS;

James Goodwine ;

Karin Sauer ;

07/29/2019

Evaluation of Cyclic Lipopeptide(s) Formulations on the Proliferation of Methicillin Resistant Staphylococcus Aureus USA300 in a Porcine Deep Partial Thickness Wound Model

Background: Chronic and acute wound infections can be difficult to treat and very costly. Novel broad-spectrum cationic antimicrobial cyclic lipopeptides (CLP) have been designe...

Alexander Higa , MA;

Joel Gil , BS, MS;

Jose Valdes , RN;

Michael Solis , MBA;

Shruti Padhee ;

David Davore ;

Richard Houghton ;

07/29/2019

Preliminary Study on the Effect of Various Antimicrobial Formulations Containing Silver Oxynitrate on Reducing Pseudomonas Aeruginosa Using an in-vivo Porcine Burn Wound Model

Background: Silver has long been known for its antimicrobial effects and has been commonly applied topically to burn wounds for years. More recently, wound dressings compounded ...

Michael Solis , MBA;

Stephen C. Davis , BS, MS;

Alexander Higa , MA;

Joel Gil , BS, MS;

Jose Valdes , RN;

07/29/2019