Yves Dauvilliers, MD, PhD

Challenges and Considerations in Design of a Placebo-Controlled, Double-Blind, Randomized-Withdrawal Study Evaluating the Efficacy and Safety of JZP-258 for the Treatment of Idiopathic Hypersomnia

No treatment is approved for idiopathic hypersomnia (IH). A retrospective chart review (Leu-Semenescu, et al. Sleep Med. 2016;17:38-44) demonstrated effectiveness of sodium oxybate (SXB) ...

Patricia Chandler , MD;

Dandan Chen , MD, PhD;

Judith Profant , PhD, MS;

Amanda Sterkel , PhD;

Yves Dauvilliers , MD, PhD;

10/08/2020

Quality of Life, Functional Evaluation, and Work Productivity in Patients With Narcolepsy: Results From a Phase 3 Study of Solriamfetol (JZP-110)

INTRODUCTION: Solriamfetol, a selective dopamine/norepinephrine reuptake inhibitor, significantly decreased excessive sleepiness in a randomized, double-blind, placebo-controlled study of...

Michael Thorpy , MD, CHBC;

Giuseppe Plazzi , MD;

Yves Dauvilliers , MD, PhD;

Colin Shapiro , PhD, FRCPC, MBBCh;

Jed Black , MD;

Geert Mayer , MD;

Helene Emsellem , MD;

Dandan Chen , MD, PhD;

Robert Ryan , MS;

Gert Jan Lammers , PhD, MD;

Chevy Chase , MD;

Lawrence Carter , PhD;

03/01/2019

Sodium Oxybate Treatment of Narcolepsy in Pediatric Patients: Long-term Efficacy and Safety

Objective: To evaluate the long-term efficacy and safety of sodium oxybate (SXB) treatment for narcolepsy in pediatric patients in a placebo-controlled, randomized-withdrawal study with a...

Carol Rosen , MD;

Chad Ruoff , MD;

Diane Guinta , PhD;

Rupa Parvataneni , MS;

Jed Black , MD;

Emmanuel Mignot , MD, PhD;

Y. Grace Wang , MD;

Giuseppe Plazzi , MD;

Yves Dauvilliers , MD, PhD;

Michel Lecendreux , MD;

03/01/2019

Efficacy of Lower-Sodium Oxybate in the Treatment of Idiopathic Hypersomnia: Evaluation of Response Based on the Idiopathic Hypersomnia Severity Scale Score

Abstract: Introduction: This post hoc analysis evaluated response to lower-sodium oxybate (LXB; Xywav®) treatment on Idiopathic Hypersomnia Severity Scale scores in a phase 3 clinical tri...

Yves Dauvilliers , MD, PhD;

Russell Rosenberg ;

01/19/2023