Moshe Fridman, PhD

Edinburgh Postnatal Depression Scale (EPDS) Total Score Remission and Number Needed to Treat (NNT) Outcomes in a Phase 3, Placebo-Controlled Trial of Zuranolone in Postpartum Depression (PPD)

Background: Zuranolone (SAGE-217) is an investigational, neuroactive steroid and GABAA receptor positive allosteric modulator evaluated in a Phase 3 trial in patients with PPD (NCT0297832...

Kristina Deligiannidis , MD;

Ellison Suthoff , MBA, BS ;

Stephen Kanes , MD, PhD;

Brian Werneburg , PhD;

Ming-Yi Huang , PhD;

Robert Lasser , MD, MBA;

Vijayveer Bonthapally , PhD;

Handan Gunduz-Bruce , MD, MBA;

Sarah Acaster , MSc;

Moshe Fridman , PhD;

10/08/2020

Correlation of HAMD-17 and EPDS Scores in a Phase 3 Trial of Zuranolone: An Oral GABAA Receptor Positive Allosteric Modulator in Postpartum Depression

Background: PPD is a common medical complication during and after pregnancy. Zuranolone (SAGE-217) is an investigational neuroactive steroid and GABAA receptor positive allosteric modulat...