Kevin L. Carter

Treatment of Benign Prostatic Hyperplasia

11/27/2012

Cincinnati—Benign prostatic hyperplasia (BPH) is the most common urological disorder in elderly men. There were an estimated 28.4 million patients with symptomatic BPH in the United States in 2010. As age increases, so does the prevalence of...

Cincinnati—Benign prostatic...

11/27/2012

First Report Managed Care

Feature

A Phase 1-2 Trial of JAK1 and JAK2 Inhibitors in Myelofibrosis

01/04/2011

Kevin L. Carter ;

Myelofibrosis, a Philadelphia chromosomenegative myeloproliferative neoplasm, is characterized by progressive anemia, bone marrow fibrosis and splenomegaly, and produces debilitating symptoms. About 50% of patients with myelofibrosis carry a...

Myelofibrosis, a Philadelphia...

01/04/2011

First Report Managed Care

Novel Monoclonal Antibody to PCSK9

07/23/2012

Kevin L. Carter ;

Studies of animal models have found that proprotein convertase subtilisin/kexin 9 (PCSK9), one of the serine proteases, has a role in the post-translational regulation of LDL-receptor activity. PCSK9, which is synthesized primarily in the...

Studies of animal models have...

07/23/2012

First Report Managed Care

News Connection

Relationship Between Primary Care Visit Duration and Quality of Care

03/02/2010

Kevin L. Carter ;

In the discussion of healthcare reform in the United States, primary care physicians have been focused on as the point practitioners in the drive to deliver higher-quality care and to lower costs.

In the discussion of healthcare...

03/02/2010

First Report Managed Care

Retinoic Acid and Arsenic Trioxide for Acute Promyelocytic Leukemia

09/19/2013

Kevin L. Carter ;

When all-trans retinoic acid (ATRA) is used with chemotherapy as the standard of care for acute promyelocytic leukemia (APL), remission rates can reach 95%, and cure rates typically exceed 80%. Arsenic trioxide with or without ATRA has also...

When all-trans retinoic acid...

09/19/2013

First Report Managed Care

Antigen Therapy for Type 1 Diabetes

03/16/2012

Kevin L. Carter ;

The onset of type 1 diabetes is manifested by the effects of inadequate insulin secretion due to the immunologic destruction of pancreatic-islet beta-cells. Even modest preservation of insulin secretion appears to reduce short- and long-term...

The onset of type 1 diabetes is...

03/16/2012

First Report Managed Care

Comparison of Pharmacy Costs Between HAART Therapies for HIV Infection

11/27/2012

Kevin L. Carter ;

The accepted therapy for HIV infection has been highly active antiretroviral therapy (HAART).

The accepted therapy for HIV...

11/27/2012

First Report Managed Care

Feature

Risk-Reducing Surgery in BRCA Mutation Carriers

01/04/2011

Kevin L. Carter ;

Women who have inherited mutations in the BRCA1 or BRCA2 genes have substantially elevated risks of breast cancer and ovarian cancer, with a lifetime risk of breast cancer of 56% to 84%.

Women who have inherited...

01/04/2011

First Report Managed Care

News

Integrated Genetic Profiling in Acute Myeloid Leukemia

07/23/2012

Kevin L. Carter ;

A series of somatic mutations that affect the progression and development of acute myeloid leukemia (AML) has recently been discovered. The prognostic relevance of cytogenetic abnormalities has led to the widespread adoption of risk...

A series of somatic mutations...

07/23/2012

First Report Managed Care

News Connection

Renal Ultrasonography and Acute Kidney Injury

02/15/2011

Kevin L. Carter ;

Acute kidney injury (AKI) is a common occurrence among hospitalized patients, with incidence increasing from 10 to 25 per 1000 discharges over the past 15 years. AKI is defined as an abrupt decline in renal function, indicated either by...

Acute kidney injury (AKI) is a...

02/15/2011

First Report Managed Care