John J. Young, MD

Case Report

Successful Exclusion of a Left Main Coronary Artery Aneurysm
with a PTFE-Covered Coronary Stent

08/01/2008

Coronary artery aneurysm (CAA), defined as localized coronary dilatation with a diameter >= 1.5 times that of the adjacent normal coronary segment, is observed in 0.2–4.9% of patients undergoing coronary angiography.1–6 CAA most often...

Coronary artery aneurysm (CAA),...

08/01/2008

Journal of Invasive Cardiology

Original Contribution

Early Revascularization and ACC/AHA Guideline-Compliant Medical Management Improve Left Ventricular Function and Short-Term Prog

08/01/2008

Santosh Menon , MD, FACC;

Eugene S. Chung , MD;

Theodore Chow , MD;

Anubhav Mital , BS;

Joseph Pastore , PhD;

Dean J. Kereiakes , MD, FACC, FSCAI;

John J. Young , MD;

Early restoration of normal coronary perfusion after myocardial infarction (MI) limits infarct size, preserves left ventricular (LV) function and reduces mortality. The primary objective of reperfusion therapy is not only to restore...

Early restoration of normal...

08/01/2008

Journal of Invasive Cardiology

Platelet Glycoprotein IIb/IIIa Inhibitor Use During Percutaneous Coronary Intervention: ‚ÄúIIb or Not IIb, What is the Question?‚Äù

08/01/2008

Dean J. Kereiakes , MD, FACC, FSCAI;

John J. Young , MD;

The primary pathophysiologic mechanism for myocardial ischemia secondary to ACS or as an acute complication of PCI is thrombotic occlusion of a coronary artery in response to vascular injury.1 Endothelial denudation caused by disruption or...

The primary pathophysiologic...

08/01/2008

Journal of Invasive Cardiology

Review

Platelet Glycoprotein IIb/IIIa Inhibition in Unstable Angina and Non-ST Segment Elevation Myocardial Infarction: Application of

08/01/2008

Dean J. Kereiakes , MD, FACC, FSCAI;

Joseph K. Choo , MD;

John J. Young , MD;

Introduction. Over the past decade, appreciable reductions in mortality, reinfarction and length of hospital stay have been reported in large-scale trials of patients with acute coronary syndromes (ACS). Every year, approximately 1.5 million...

Introduction. Over the past...

08/01/2008

Journal of Invasive Cardiology

The Angiomax Peripheral Procedure Registry of Vascular Events Trial (APPROVE): In-Hospital and 30-Day Results

08/01/2008

David E. Allie , MD;

John J. Young , MD;

John R. Laird , MD, FACC, FACP;

Patrick Hall , MD;

Nicolas W. Shammas , MD, MS, FACC, FSCAI, FACP, FSVM;

Robert Safian , MD;

Ajay Virmani , MD;

Peripheral arterial disease (PAD) affects 8–12 million Americans with an estimated 12–20% of the population > 65 years of age afflicted. Approximately 50% of patients are asymptomatic, which may explain why this disease is often...

Peripheral arterial disease...

08/01/2008

Journal of Invasive Cardiology

Predictors of In-hospital and 30-day Complications of Peripheral Vascular Interventions Using Bivalirudin as the Primary Anticoa

08/01/2008

Patrick Hall , MD;

Robert Safian , MD;

Ajay Virmani , MD;

Nicolas W. Shammas , MD, MS, FACC, FSCAI, FACP, FSVM;

John J. Young , MD;

David E. Allie , MD;

John R. Laird , MD, FACC, FACP;

Predictors of complications in peripheral percutaneous interventions (PPI) with bivalirudin as a base anticoagulant have not yet been defined. The Angiomax Peripheral Procedure Registry of Vascular Events (APPROVE)1 offers a unique...

Predictors of complications in...

08/01/2008

Journal of Invasive Cardiology

Commentary

Combination Antiplatelet Therapy Following Brachytherapy with Restenting: ‚ÄúIt Ain‚Äôt Over ‚Äòtil the Fat Lady Sings‚Äù

08/01/2008

John J. Young , MD;

Dean J. Kereiakes , MD, FACC, FSCAI;

Joseph K. Choo , MD;

Thomas M. Broderick , MD;

Coronary vascular brachytherapy reduces recurrent restenosis and is a valuable adjunct to percutaneous coronary intervention (PCI) in the treatment of in-stent restenosis (level of evidence A).1–3 Although both late (6 month) coronary...

Coronary vascular brachytherapy...

08/01/2008

Journal of Invasive Cardiology

Commentary

Thrombosis, Inflammation, and Our Evolving Understanding
of Vascular Biology during Interventional Therapy

08/01/2008

John J. Young , MD;

Peripheral arterial disease (PAD) is a problem of substantial public health importance. The disorder is estimated to affect 27 million people in Europe and North America alone.1 Recent data have consistently revealed a sharp increase in PAD...

Peripheral arterial disease...

08/01/2008

Journal of Invasive Cardiology

Commentary

Adjunctive Antiplatelet Therapy during Rescue PCI

08/01/2008

John J. Young , MD;

Dean J. Kereiakes , MD, FACC, FSCAI;

The treatment of ST-segment elevation myocardial infarction (STEMI) continues to evolve due to the adoption of antiplatelet and anticoagulation regimens in combination with pharmacologic (fibrinolysis) and/or mechanical reperfusion. Rapid,...

The treatment of ST-segment...

08/01/2008

Journal of Invasive Cardiology

Commentary

Platelet Glycoprotein IIb/IIIa Inhibition as Adjunctive Therapy during Primary Percutaneous Coronary Intervention for Acute St-s

08/01/2008

John J. Young , MD;

Approximately 1.1 million myocardial infarctions occur annually in the United States and result in about 500,000 deaths. Acute myocardial infarction (AMI) is the result of plaque rupture and thrombus formation, with subsequent occlusion of a...

Approximately 1.1 million...

08/01/2008

Journal of Invasive Cardiology