Patricia Chandler, MD

Challenges and Considerations in Design of a Placebo-Controlled, Double-Blind, Randomized-Withdrawal Study Evaluating the Efficacy and Safety of JZP-258 for the Treatment of Idiopathic Hypersomnia

No treatment is approved for idiopathic hypersomnia (IH). A retrospective chart review (Leu-Semenescu, et al. Sleep Med. 2016;17:38-44) demonstrated effectiveness of sodium oxybate (SXB) ...

Patricia Chandler , MD;

Dandan Chen , MD, PhD;

Judith Profant , PhD, MS;

Amanda Sterkel , PhD;

Yves Dauvilliers , MD, PhD;

10/08/2020

Long-Term Safety and Maintenance of Efficacy of Solriamfetol (JZP-110) in the Treatment of Excessive Sleepiness in Participants With Narcolepsy or Obstructive Sleep Apnea

INTRODUCTION: Excessive sleepiness (ES) is a prominent symptom of narcolepsy and obstructive sleep apnea (OSA). Solriamfetol, a selective dopamine/norepinephrine reuptake inhibitor, was e...

Colin Shapiro , PhD, FRCPC, MBBCh;

Richard Schwab , MD;

Jean-Louis Pepin , MD;

Jan Hedner , MD;

Mansoor Ahmed , MD;

Nancy Foldvary-Schaefer , DO, MS;

Patrick Strollo , MD;

Geert Mayer , MD;

Kathleen Sarmiento , MD, MPH;

Michelle Baladi , PhD;

Patricia Chandler , MD;

Lawrence Lee , PhD;