BackgroundRAS genes are prognostic and predictive genetic biomarkers for the anti-EGFR treatment in metastatic colorectal cancer (mCRC), having an important impact on treatment management...
BackgroundTime to take medical decision is very important for cancer patients. In general patients demand and require answers to understand their oncology disease. In the last years genom...
BackgroundSidedness of colorectal cancer (CRC) can reveal different presentation, molecular alteration, histology, and outcome. Left-sided CRC are known to have a better prognosis in term...
BackgroundEsophageal cancer (EC) patients suffer from significant cachexia prior to and during treatment with chemotherapy and radiation (CRT). Feeding tubes can become the primary form o...
BackgroundRegorafenib is considered the standard third-line therapy of mCRC, which has demonstrated a survival benefit over placebo in randomized trials. Another, less proven approach is ...
BackgroundPancreatic cancer is the fourth deadliest cancer for both men and women. Current five-year survival rate is 12% increased to 44% for the 15% with localized disease and most pati...
BackgroundGISTs are rare; constituting 1% of all sarcomas and 3–5% of gastrointestinal tumors1. Most frequently originated from the stomach and small intestine2. There are several tumours...
BackgroundSeveral DNA repair pathways are implicated in heriditary colorectal cancer predisposition. Mismatch Repair (MMR) is the most common repair system of damaged DNA and in maintaini...
BackgroundGastric cancer (GC) is the fifth leading cause of cancer incidence, and fourth in mortality worldwide. The LEGACy study is a multi-institutional study between Europe and Latin A...
BackgroundChemoradiation with Cape – RT is the standard of care in patients with LARC, though total neoadjuvant therapy might improve survival outcomes. Establishing baseline outcomes wit...