Larry Culpepper, MD

Post hoc Analysis of the Efficacy and Safety of Lemborexant in Adults with Insomnia Disorder and Depression History

Introduction: Study 303 (SUNRISE-2; NCT02952820) evaluated lemborexant (LEM) efficacy in subjects with insomnia. This post-hoc analysis examined sleep outcomes in the subgroup of subjects...

Larry Culpepper , MD;

Andrew Krystal , MD;

Jane Yardley , PhD;

Kate Pinner , MSc;

Naoki Kubota ;

Margaret Moline , PhD;

Jess Amchin , MD, JD;

Norman Atkins Jr., MBA, PhD;

Manoj Malhotra , MD;

Andrew Nierenberg , MD, MGH;

10/08/2020

Effects of Cariprazine on Prolactin Levels in Patients With Bipolar I Disorder

Background: Antipsychotic treatment has been linked to hyperprolactinemia, which can lead to increased nonadherence and changes in sexual hormones in both men and women. Here, we evaluate...

Mehul Patel , MD, PharmD;

Larry Culpepper , MD;

Deanna Kelly ;

Eduard Vieta , MD, PhD;

Thais Moreira , PharmD, PhD;

Willie Earley , MD;

11/22/2019

Vilazodone Efficacy Across Somatic and Psychic Symptoms of Depression: A Pooled Analysis From 4 Randomized and Placebo-Controlled Studies

Background: Vilazodone (VLZ) is a serotonin reuptake inhibitor and 5-HT1A receptor partial agonist approved for the treatment of Major Depressive Disorder (MDD). Historically, MDD studies...

Larry Culpepper , MD;

Pratap Chokka , MD, FRACP;

Ken Kramer , PhD;

11/22/2019