Daryl DeKarske, MPH

Depression in Parkinson`s Disease: Investigations of Pimavanserin, a Selective 5-HT2A Receptor Antagonist/Inverse Agonist

Depression occurs in 30–50% of Parkinson’s disease (PD) patients, yet no drugs are approved specifically to treat PD patients with depressive symptoms. Few clinical studies have been cond...

Rene Nunez , MD;

Maurizio Fava , MD, PhD;

Daryl DeKarske , MPH;

Lori Jacobi , BA;

Bruce Coate , MPH;

Keith Liu , PhD;

Susan Legacy , MD;

Bryan Dirks , MD, MSc, MBA;

10/08/2020

Open-Label Study of Pimavanserin Patients With Comorbid Parkinson’s Disease and Depression

Depression occurs in ~50% of Parkinson’s disease (PD) patients, increases in severity as the disease progresses, and is associated with increased morbidity. We are assessing use of pimava...

Daryl DeKarske , MPH;

Bruce Coate , MPH;

James C. Norton , PhD;

Michael Guskey , PharmD;

Gustavo Alva , MD, DFAAPA;

Jason Aldred , MD, FAAN;

Marc Cantillon , MD;

11/22/2019