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Journal of Critical Limb Ischemia

Explore the Journal of Critical Limb Ischemia (JCLI), a quarterly international peer-reviewed journal and online clinical resource for those treating chronic limb-threatening ischemia. JCLI is the official journal of the CLI Global Society.

Recently Published

Original Research
06/10/2026
Bruno Migliara, MD, PhD; Daniela Cazzato, PhD; Cristian Nicoletti, MD; Giovanni Feriani, MD; Nicola Raschellà; Andrea Marcellusi, PhD; Chiara Bini, MSc
The authors evaluate health care resource utilization and hospital costs associated with pDVA in patients with CLTI.
The authors evaluate health care resource utilization and hospital costs associated with pDVA in patients with CLTI.
The authors evaluate health care...
06/10/2026
Journal of Critical Limb Ischemia
Original Research
06/02/2026
Elisa Amato, DPM; Simone Barbagallo, PhD; Francesco Giangreco, MD; Alberto Piaggesi, MD
Diabetologists of the Tuscany Regional Health Service realized an initiative called the Diabetic Foot Valley Project to create a community of practice including physicians, nurses, and podiatrists.
Diabetologists of the Tuscany Regional Health Service realized an initiative called the Diabetic Foot Valley Project to create a community of practice including physicians, nurses, and podiatrists.
Diabetologists of the Tuscany...
06/02/2026
Journal of Critical Limb Ischemia
Review
05/26/2026
Md. Mojahidur Hasan, MBBS, MMSc; Sehreen Tory, MBBS, MMSc; Yusuf Tutar, PhD
In this scoping review, Web of Science, PubMed, and Scopus databases were searched to find studies that evaluated the effects of stem cell–derived EVs in treating animal models of CLTI.
In this scoping review, Web of Science, PubMed, and Scopus databases were searched to find studies that evaluated the effects of stem cell–derived EVs in treating animal models of CLTI.
In this scoping review, Web of...
05/26/2026
Journal of Critical Limb Ischemia
Review
05/26/2026
Matthew T. Finn, MD, MSc; Saami K. Yazdani, PhD; McCall Walker, MD; Tatsuya Nakama, MD; Mahmoud Abdelghany, MD; Sonal Pruthi, MD; Robert S. Zilinyi, MD; Daniel J. Snyder, MD; Zola N'Dandu, MD; Sahil A. Parikh, MD, FACC, FSCAI; Craig M. Walker, MD, FACC, FACP, FSCAI, FCCP; Pradeep K. Nair, MD, FACC, FSCAI
This review provides a detailed discussion of research evaluating paclitaxel and alternative drug-coated therapies within the context of contemporary treatment of CLTI.
This review provides a detailed discussion of research evaluating paclitaxel and alternative drug-coated therapies within the context of contemporary treatment of CLTI.
This review provides a detailed...
05/26/2026
Journal of Critical Limb Ischemia
Case Report
05/05/2026
Grant Killian, MS; Richard Neville, MD
This case report describes bilateral surgical bypass in a patient with “no-option” chronic limb-threatening ischemia.
This case report describes bilateral surgical bypass in a patient with “no-option” chronic limb-threatening ischemia.
This case report describes...
05/05/2026
Journal of Critical Limb Ischemia
Literature Review
03/31/2026
Jeffrey G. Carr, MD, FACC, FSCAI; Ralf Langhoff, MD; Brian DeRubertis, MD, FACS; Kristin L. Hood, PhD; Prakash Krishnan, MD, FACC; Vikram Puttaswamy, MD; Thomas Zeller, MD, PhD; Eric A. Secemsky, MD, MSc, RPVI, FACC, FAHA, FSCAI
In this literature review, the authors aim to comprehensively summarize the evidence quality and clinical outcomes following peripheral atherectomy in patients with and without CLTI.
In this literature review, the authors aim to comprehensively summarize the evidence quality and clinical outcomes following peripheral atherectomy in patients with and without CLTI.
In this literature review, the...
03/31/2026
Journal of Critical Limb Ischemia
Editorial/Commentary
03/31/2026
Dipankar Mukherjee, MD, FACS; Richard Neville, MD
The authors comment on the article by Carr et al, "Outcomes in Patients With and Without Chronic Limb-Threatening Ischemia: A Systematic Literature Review on Atherectomy for Peripheral Interventions".
The authors comment on the article by Carr et al, "Outcomes in Patients With and Without Chronic Limb-Threatening Ischemia: A Systematic Literature Review on Atherectomy for Peripheral Interventions".
The authors comment on the...
03/31/2026
Journal of Critical Limb Ischemia
Dr Fabrizio Fanelli speaks at ISET 2026.
ISET 2026
03/30/2026
Fabrizio Fanelli, MD
In this video from ISET 2026, Fabrizio Fanelli, MD, from Careggi University Hospital in Florence, Italy, explores the evolving role of specialty balloons in the treatment of tibial vessel disease.
In this video from ISET 2026, Fabrizio Fanelli, MD, from Careggi University Hospital in Florence, Italy, explores the evolving role of specialty balloons in the treatment of tibial vessel disease.
In this video from ISET 2026,...
03/30/2026
Journal of Critical Limb Ischemia
Case Series
03/13/2026
Anxhela Hasanlli, MD; John H. Rundback, MD, FAHA, FSVM, FSIR; Kevin Herman, MD; Edel Mendoza, MD
The authors present a retrospective case series of 3 patients with ALI who underwent DVA due to persistent, unresolvable limb-threatening tibiopedal occlusive disease after failed endovascular or surgical procedures.
The authors present a retrospective case series of 3 patients with ALI who underwent DVA due to persistent, unresolvable limb-threatening tibiopedal occlusive disease after failed endovascular or surgical procedures.
The authors present a...
03/13/2026
Journal of Critical Limb Ischemia
Clinical Trials
03/12/2026
HELSINKI, March 12, 2026 (GLOBE NEWSWIRE) -- Aplagon, a clinical stage biotech pioneering a first-in-class treatment for thrombo-inflammatory diseases, known as APAC, a heparin proteoglycan mimetic with antiplatelet and anticoagulant...
HELSINKI, March 12, 2026 (GLOBE NEWSWIRE) -- Aplagon, a clinical stage biotech pioneering a first-in-class treatment for thrombo-inflammatory diseases, known as APAC, a heparin proteoglycan mimetic with antiplatelet and anticoagulant...
HELSINKI, March 12, 2026 (GLOBE...
03/12/2026
Journal of Critical Limb Ischemia
Narrative Review
02/23/2026
Eric Ducasse, MD, PhD; Xavier Bérard, MD, PhD; Caroline Caradu, MD, PhD
This review examines CLTI as a systems disease, focusing on failure points in recognition, referral, and access; why delays translate into limb loss and death; organizational models that mitigate delay; and more.
This review examines CLTI as a systems disease, focusing on failure points in recognition, referral, and access; why delays translate into limb loss and death; organizational models that mitigate delay; and more.
This review examines CLTI as a...
02/23/2026
Journal of Critical Limb Ischemia

Current Issue

Case Report
05/05/2026
Grant Killian, MS; Richard Neville, MD
This case report describes bilateral surgical bypass in a patient with “no-option” chronic limb-threatening ischemia.
This case report describes bilateral surgical bypass in a patient with “no-option” chronic limb-threatening ischemia.
This case report describes...
05/05/2026
Journal of Critical Limb Ischemia
Review
05/26/2026
Matthew T. Finn, MD, MSc; Saami K. Yazdani, PhD; McCall Walker, MD; Tatsuya Nakama, MD; Mahmoud Abdelghany, MD; Sonal Pruthi, MD; Robert S. Zilinyi, MD; Daniel J. Snyder, MD; Zola N'Dandu, MD; Sahil A. Parikh, MD, FACC, FSCAI; Craig M. Walker, MD, FACC, FACP, FSCAI, FCCP; Pradeep K. Nair, MD, FACC, FSCAI
This review provides a detailed discussion of research evaluating paclitaxel and alternative drug-coated therapies within the context of contemporary treatment of CLTI.
This review provides a detailed discussion of research evaluating paclitaxel and alternative drug-coated therapies within the context of contemporary treatment of CLTI.
This review provides a detailed...
05/26/2026
Journal of Critical Limb Ischemia
Review
05/26/2026
Md. Mojahidur Hasan, MBBS, MMSc; Sehreen Tory, MBBS, MMSc; Yusuf Tutar, PhD
In this scoping review, Web of Science, PubMed, and Scopus databases were searched to find studies that evaluated the effects of stem cell–derived EVs in treating animal models of CLTI.
In this scoping review, Web of Science, PubMed, and Scopus databases were searched to find studies that evaluated the effects of stem cell–derived EVs in treating animal models of CLTI.
In this scoping review, Web of...
05/26/2026
Journal of Critical Limb Ischemia
Original Research
06/02/2026
Elisa Amato, DPM; Simone Barbagallo, PhD; Francesco Giangreco, MD; Alberto Piaggesi, MD
Diabetologists of the Tuscany Regional Health Service realized an initiative called the Diabetic Foot Valley Project to create a community of practice including physicians, nurses, and podiatrists.
Diabetologists of the Tuscany Regional Health Service realized an initiative called the Diabetic Foot Valley Project to create a community of practice including physicians, nurses, and podiatrists.
Diabetologists of the Tuscany...
06/02/2026
Journal of Critical Limb Ischemia
Original Research
06/10/2026
Bruno Migliara, MD, PhD; Daniela Cazzato, PhD; Cristian Nicoletti, MD; Giovanni Feriani, MD; Nicola Raschellà; Andrea Marcellusi, PhD; Chiara Bini, MSc
The authors evaluate health care resource utilization and hospital costs associated with pDVA in patients with CLTI.
The authors evaluate health care resource utilization and hospital costs associated with pDVA in patients with CLTI.
The authors evaluate health care...
06/10/2026
Journal of Critical Limb Ischemia

Videos & Interviews

Dr Fabrizio Fanelli speaks at ISET 2026.
ISET 2026
03/30/2026
Fabrizio Fanelli, MD
In this video from ISET 2026, Fabrizio Fanelli, MD, from Careggi University Hospital in Florence, Italy, explores the evolving role of specialty balloons in the treatment of tibial vessel disease.
In this video from ISET 2026, Fabrizio Fanelli, MD, from Careggi University Hospital in Florence, Italy, explores the evolving role of specialty balloons in the treatment of tibial vessel disease.
In this video from ISET 2026,...
03/30/2026
Journal of Critical Limb Ischemia
Dr van den Berg
Videos
12/02/2024
Jos C. van den Berg, MD, PhD; Thomas Zeller, MD, PhD
CLI Global Society European Chapter Chairman Jos van den Berg, MD, and Vice-Chairman Thomas Zeller, MD, discuss the work that the Chapter has been doing to improve the lives of patients with CLTI.
CLI Global Society European Chapter Chairman Jos van den Berg, MD, and Vice-Chairman Thomas Zeller, MD, discuss the work that the Chapter has been doing to improve the lives of patients with CLTI.
CLI Global Society European...
12/02/2024
Journal of Critical Limb Ischemia
Abigail Mize
Videos
11/25/2024
Abigail Mize, BS, RDCS, RVT; David B. Alper, DPM
11/25/2024
Journal of Critical Limb Ischemia
Dr Katzen
Videos
11/18/2024
Barry T. Katzen, MD, FACC, FACR, FSIR
11/18/2024
Journal of Critical Limb Ischemia
Videos
11/13/2024
Fadi Saab, MD, FACC, FSCAI; Zola N'Dandu, MD; Khanjan Nagarsheth, MD, MBA, RPVI; Bret N. Wiechmann, MD, FSIR, FAHA
11/13/2024
Journal of Critical Limb Ischemia
Videos
09/11/2024
Journal of Critical Limb Ischemia
Videos
09/10/2024
Journal of Critical Limb Ischemia

Original Research

Original Contribution
07/08/2025
Arnaud Kerzmann, MD; Justine Pudzeis, MD; Evelyne Boesmans, MD; Charlotte Praca, MD; Philippe Brion, MD; Vlad Adrian Alexandrescu, MD, PhD; Vincent Tchana-Sato, MD, PhD
The authors present 2 cases of vessel preparation where the Rotarex S rotational atherothrombectomy device induced arterial wall ruptures and describe how the ruptures were treated in 2 different ways. 
The authors present 2 cases of vessel preparation where the Rotarex S rotational atherothrombectomy device induced arterial wall ruptures and describe how the ruptures were treated in 2 different ways. 
The authors present 2 cases of...
07/08/2025
Journal of Critical Limb Ischemia
Original Contribution
04/14/2025
David Heister, MD, PhD; Taylor Pickering, DO; Sameh M. Sayfo, MD, MBA, FABVM
This report describes a case of computed tomography-guided lumbar sympathectomy for palliative treatment of severe rest pain in a patient who was not a candidate for either open or endovascular treatments.
This report describes a case of computed tomography-guided lumbar sympathectomy for palliative treatment of severe rest pain in a patient who was not a candidate for either open or endovascular treatments.
This report describes a case of...
04/14/2025
Journal of Critical Limb Ischemia
Original Contribution
04/02/2025
Ahmad Hallak, MD; Naveed S. Zaman, BS; Ayitevi Agbodji, MD, MPH; Mukosolu Florence Obi, MD; Jonathan Bonilla, MD; Zola N'Dandu, MD
The authors present the case of a 64-year-old man with renal insufficiency and CLTI complicated by a nonhealing ulcer who was successfully revascularized using deep venous arterialization with zero iodinated contrast technique.
The authors present the case of a 64-year-old man with renal insufficiency and CLTI complicated by a nonhealing ulcer who was successfully revascularized using deep venous arterialization with zero iodinated contrast technique.
The authors present the case of...
04/02/2025
Journal of Critical Limb Ischemia
Original Contribution
02/12/2024
Mahmoud Abdelghany, MD; Larry J. Diaz-Sandoval, MD; Lorenzo Patrone, MD; Edoardo Pasqui, MD; Tatsuya Nakama, MD; Imraan Ansaarie, MD; Mario D'Oria, MD; Fadi Saab, MD, FACC, FSCAI; Erwin Blessing, MD; Eric J. Dippel, MD; Mohammad M. Ansari, MD; Anahita Dua, MD, MS, MBA, FACS; Grigorios Korosoglou, MD; Mazin I. Foteh, MD; Sreekumar Madassery, MD; Zola N'Dandu, MD; Bob Tahara, MD; Bret N. Wiechmann, MD, FSIR, FAHA; John G. Winscott, MD; David Yeager, DPM, FASPS, FACFAS; Athanasios Saratzis, MD; M. Laiq Raja, MD
In this article, the authors discuss the historical definitions of CLTI and provide an overview of how the management of patients with CLTI has developed, including surgical and endovascular interventions.
In this article, the authors discuss the historical definitions of CLTI and provide an overview of how the management of patients with CLTI has developed, including surgical and endovascular interventions.
In this article, the authors...
02/12/2024
Journal of Critical Limb Ischemia
Original Contribution
01/04/2024
Michael Siah, MD; Mehmet A. Suludere; Lawrence A. Lavery, DPM, MPH; Gerardo Gonzalez-Guardiola, MD; Tiffany Guard, MS; Melissa L Kirkwood, MD
The objective of this study was to demonstrate the feasibility of subintimal implantation of interwoven nitinol stents in CLTI patients with chronically occluded superficial superior artery and popliteal stents.
The objective of this study was to demonstrate the feasibility of subintimal implantation of interwoven nitinol stents in CLTI patients with chronically occluded superficial superior artery and popliteal stents.
The objective of this study was...
01/04/2024
Journal of Critical Limb Ischemia
Original Contribution
09/29/2023
Katherine L. Morrow, MD; Mazin I. Foteh, MD; Anahita Dua, MD, MS, MBA, FACS
This article describes the patient selection criteria, procedural overview, and postoperative surveillance strategies for open lower extremity distal bypass surgery in patients with long-segment superficial femoral artery disease.
This article describes the patient selection criteria, procedural overview, and postoperative surveillance strategies for open lower extremity distal bypass surgery in patients with long-segment superficial femoral artery disease.
This article describes the...
09/29/2023
Journal of Critical Limb Ischemia
Original Contribution
12/28/2022
Sasha P. Suárez Ferreira, BS; Anahita Dua, MD, MS, MBA, FACS
The pathophysiology, risk factors, clinical presentation, diagnosis, management, outcomes, and quality of life of women with PAD are reviewed.
The pathophysiology, risk factors, clinical presentation, diagnosis, management, outcomes, and quality of life of women with PAD are reviewed.
The pathophysiology, risk...
12/28/2022
Journal of Critical Limb Ischemia
Original Contribution
09/28/2021
M. Imran Ghare, MD; Cody Pietras, BA; Daniela Tirziu, PhD; Helen Parise, ScD; Roseann White, PhD; S. Elissa Altin, MD; Sameer Nagpal, MD; Alexandra J. Lansky, MD
The authors selected studies reporting amputation-free survival (AFS) in patients with non-revascularizable Rutherford category 5/6 CLI at a minimum follow-up of 6 months.
The authors selected studies reporting amputation-free survival (AFS) in patients with non-revascularizable Rutherford category 5/6 CLI at a minimum follow-up of 6 months.
The authors selected studies...
09/28/2021
Journal of Critical Limb Ischemia
Original Contribution
09/28/2021
Jihad A. Mustapha, MD, FACC, FSCAI; Fadi Saab, MD, FACC, FSCAI; Theresa McGoff, BSN; Sara Finton, BSN; George L. Adams, MD, MHS, MBA, FACC, FSCAI; J. Randall Mullins, MD; Michael R. Jaff, MD, DO; Farhan Khawaja, MD; Philip P. Goodney, MD; Gabor Matos, MD; M. Laiq Raja, MD; Michael Sumners, DO
The objective of this study was to determine the relationship between patients diagnosed with PAD/CLI, with CTOs, and subsequent long-term outcomes.
The objective of this study was to determine the relationship between patients diagnosed with PAD/CLI, with CTOs, and subsequent long-term outcomes.
The objective of this study was...
09/28/2021
Journal of Critical Limb Ischemia
Original Contribution
09/28/2021
Omid Shafe, MD; Ehsan Samiee, MD; Jamal Moosavi, MD; Bahram Mohebbi, MD; Amir A. Fakhrabadi, MD; Hooman Bakhshandeh, MD, PhD; Batoul Naghavi, MD, MPH; Reza Tahivili; Saeed Cheraghi; Parham Sadeghipour, MD
This randomized, controlled trial was designed to compare the rate of postangiographic contrast-induced nephropathy between the intra-arterial injections of carbon dioxide and the iodinated contrast agent.
This randomized, controlled trial was designed to compare the rate of postangiographic contrast-induced nephropathy between the intra-arterial injections of carbon dioxide and the iodinated contrast agent.
This randomized, controlled...
09/28/2021
Journal of Critical Limb Ischemia

Editorial/Commentary

Editorial/Commentary
03/31/2026
Dipankar Mukherjee, MD, FACS; Richard Neville, MD
The authors comment on the article by Carr et al, "Outcomes in Patients With and Without Chronic Limb-Threatening Ischemia: A Systematic Literature Review on Atherectomy for Peripheral Interventions".
The authors comment on the article by Carr et al, "Outcomes in Patients With and Without Chronic Limb-Threatening Ischemia: A Systematic Literature Review on Atherectomy for Peripheral Interventions".
The authors comment on the...
03/31/2026
Journal of Critical Limb Ischemia
Editorial/Commentary
07/23/2025
Marta Lobato, MD; August Ysa, MD, EBVS
Drs Lobato and Ysa review the article "A Systematic Review of Clinical Trials in Patients With Critical Limb-Threatening Ischemia” by Nagarsheth et al.
Drs Lobato and Ysa review the article "A Systematic Review of Clinical Trials in Patients With Critical Limb-Threatening Ischemia” by Nagarsheth et al.
Drs Lobato and Ysa review the...
07/23/2025
Journal of Critical Limb Ischemia
Editorial/Commentary
01/29/2025
Aishwarya Raja, MD; Eric A. Secemsky, MD, MSc, RPVI, FACC, FAHA, FSCAI
In the latest issue of JACC: Cardiovascular Interventions, Raja et al analyzed trends in the institutional use of endovascular revascularization and surgical bypass among 196,070 Medicare beneficiaries aged 66 and older with CLI.
In the latest issue of JACC: Cardiovascular Interventions, Raja et al analyzed trends in the institutional use of endovascular revascularization and surgical bypass among 196,070 Medicare beneficiaries aged 66 and older with CLI.
In the latest issue of JACC:...
01/29/2025
Journal of Critical Limb Ischemia
Editorial/Commentary
06/20/2024
Christos Dimopoulos, MD, PhD; Theodosios Bisdas, MD, PhD
Phantom limb pain (PLP) encapsulates the complex spectrum of pain, both physical and psychological. Understanding and treating PLP requires a holistic approach that considers the intricate interplay between the brain, body, and mind.
Phantom limb pain (PLP) encapsulates the complex spectrum of pain, both physical and psychological. Understanding and treating PLP requires a holistic approach that considers the intricate interplay between the brain, body, and mind.
Phantom limb pain (PLP)...
06/20/2024
Journal of Critical Limb Ischemia
Editorial/Commentary
03/18/2024
Theodosios Bisdas, MD, PhD; Konstantinos Stavroulakis, MD
Abdelghany et al, acting on behalf of the Publication Committee of the Critical Limb Ischemia Global Society, presented an insightful analysis detailing the historical progression of CLTI treatment. This historical journey has been marked by...
Abdelghany et al, acting on behalf of the Publication Committee of the Critical Limb Ischemia Global Society, presented an insightful analysis detailing the historical progression of CLTI treatment. This historical journey has been marked by...
Abdelghany et al, acting on...
03/18/2024
Journal of Critical Limb Ischemia
Editorial/Commentary
03/14/2024
Sean W. Dooley, MD; Eric A. Secemsky, MD, MSc, RPVI, FACC, FAHA, FSCAI; Michael R. Jaff, MD, DO
In this commentary, the authors address the current challenges in CLTI care.
In this commentary, the authors address the current challenges in CLTI care.
In this commentary, the authors...
03/14/2024
Journal of Critical Limb Ischemia
Editorial/Commentary
01/10/2024
Fadi Saab, MD, FACC, FSCAI; Khanjan Nagarsheth, MD, MBA, RPVI
Drs. Saab and Nagarsheth provide commentary on the article "The Tack-Optimized Balloon Angioplasty (TOBA) II Below-the-Knee Trial: 36-Month Results" by Adams, et al. 
Drs. Saab and Nagarsheth provide commentary on the article "The Tack-Optimized Balloon Angioplasty (TOBA) II Below-the-Knee Trial: 36-Month Results" by Adams, et al. 
Drs. Saab and Nagarsheth provide...
01/10/2024
Journal of Critical Limb Ischemia
Editorial/Commentary
01/10/2024
Zola N'Dandu, MD
Dr. N'Dandu comments on the article "Outcomes of Reintervention in Percutaneous Deep Venous Arterialization" by Zaman et al.
Dr. N'Dandu comments on the article "Outcomes of Reintervention in Percutaneous Deep Venous Arterialization" by Zaman et al.
Dr. N'Dandu comments on the...
01/10/2024
Journal of Critical Limb Ischemia
Editorial/Commentary
09/29/2023
Grigorios Korosoglou, MD; Erwin Blessing, MD
The authors comment on the article by Papoyan et al, "Retrograde Pedal Access for the Superficial Femoral Artery Recanalization In Critical Limb Ischemia."
The authors comment on the article by Papoyan et al, "Retrograde Pedal Access for the Superficial Femoral Artery Recanalization In Critical Limb Ischemia."
The authors comment on the...
09/29/2023
Journal of Critical Limb Ischemia
Editorial/Commentary
06/11/2023
Constantino S. Peña, MD, FAHA, FSCCT, FSIR
The need for cost-effective, quality care will drive patient treatment decisions and trends. Traditionally, the transfemoral approach has offered a dependable primary access site particularly to approach lower extremity disease. Why should...
The need for cost-effective, quality care will drive patient treatment decisions and trends. Traditionally, the transfemoral approach has offered a dependable primary access site particularly to approach lower extremity disease. Why should...
The need for cost-effective,...
06/11/2023
Journal of Critical Limb Ischemia