Risk Factors for Inverted Papilloma-Associated Squamous Cell Carcinoma

According to a recent study published in The Laryngoscope, patients with sinonasal inverted papilloma (IP) who have a history of smoking, facial pain, epistaxis, and bony destruction may be at a higher risk for inverted papilloma-associated squamous cell carcinoma (IP-SCC).

Researchers aimed to investigate significant clinicoradiologic remarks associated with IP-SCC in a retrospective study evaluating the postoperative surgical specimens of 44 patients with IP-SCC and 301 patients with IP. Specimens were obtained from patients with confirmed IP or IP-SCC at a single tertiary medical center from 1997 to 2018. Patients' demographic and clinical characteristics, preoperative in-office punch biopsy results, and preoperative computed tomography or magnetic resonance images were reviewed.

Factors associated with IP-SCC include tobacco smoking, facial pain, bony destruction, bony remodeling, and invasion of adjacent structures.

“IP patients with a history of tobacco smoking, facial pain, epistaxis, and bony destruction, remodeling, or invasion of an adjacent structure on preoperative images may be at higher risk for IP-SCC,” concluded the study authors.

Reference
Park MJ, Cho W, Kim JH, Chung YS, Jang YJ, Yu MS. Preoperative prediction of sinonasal inverted papilloma-associated squamous cell carcinoma (IP-SCC). Laryngoscope. Published online January 23, 2023. doi:10.1002/lary.30583